Even if she kept gaining she probably wouldn't develop health problem due to her weight any time soon. Fat that accumulates on the lower body (ass, hips and thighs), which is subcutaneous, generally doesn't bring any harm. To some degree it can even be benefical (although i don't have exact numbers). Most comorbities associated with obesity comes from fat stored in the middle. Specifically visceral fat is the most harmful (the one that makes your belly look like an inflated ball). In her case she kinda won the genetic lottery in that sense, as her belly has much less fat compared to her hips, and it looks pretty soft, so she probably have a low amount of visceral fat. Its all speculation of course, but given her weight distribution i don't believe she has weight related health issues nor would develop even with a couple pounds more.
As for Randalin, she falls on the same case, just a lot more extreme. She hasn't related any health problems (understandable, that's none of our concern really) but she does struggle with mobility, and i'd guess she has self-image problems due to how large she is, so it could affect her mental negativetely. Also she doesn't seem to exercise, so her bones and muscles must suffer a lot carrying all the weight around, while lowkey seems quite active. But then again, supposing the guesses in this thread are right and lowkey weighs about 200 lbs (is there any confirmation?), Randalin has weighed in at over 400 lbs in one of her videos, that's two times lowkey, and i don't think she'd ever get nearly close to that. Randalin is way over the mark of morbid obesity.